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KMID : 0604520220480010033
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Journal of the Society of Cosmetic Scientists of Korea
2022 Volume.48 No. 1 p.33 ~ p.38
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Protective Effect of Glycyrrhiza glabra Extract on UV-induced Skin DNA Damage
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Shin Jae-Young
Kang Nae-Gyu
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Abstract
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Ultraviolet B (UVB) damages DNA residues in skin keratinocytes. In particular, the formation of cyclobutane pyrimidine dimers (CPD), a pyrimidine residue damage in DNA, is considered a representative indicator of skin photoaging.
In this study, we confirmed defensive effect of Glycyrrhiza glabra (G. glabra) extract against UVB induced DNA damage.
First of all, we confirmed UVB dependent amount of CPD formation in human keratinocyte cell line. UVB induced CPD was decreased by G. glabra extract by dose dependent manner. In addition, it was confirmed that the expression of mRNA of DNA damage recovery factors was increased by G. glabra extract. Consequently, through this study, it was possible to confirm the DNA protection effect of G. glabra extract in skin keratinocytes.
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KEYWORD
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ultraviolet B, Glycyrrhiza glabra, CPD, DNA damage, DNA repair
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